1999•Antimicrobial Agents and ChemotherapyOpen access
Amphotericin B- and Fluconazole-Resistant Candida spp., Aspergillus fumigatus , and Other Newly Emerging Pathogenic Fungi Are Susceptible to Basic Antifungal Peptides
Eva J. Helmerhorst, Ingrid M. Reijnders, Wim van ‘t Hof, Ina M. Simoons-Smit, Enno C.I. Veerman, Arie V. Nieuw Amerongen
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Abstract
The present study shows that a number of basic antifungal peptides, including human salivary histatin 5, a designed histatin analog designated dhvar4, and a peptide from frog skin, PGLa, are active against amphotericin B-resistant Candida albicans, Candida krusei, and Aspergillus fumigatus strains and against a fluconazole-resistant Candida glabrata isolate.