2002•Antimicrobial Agents and ChemotherapyOpen access

Pharmacodynamic Interaction of Doxycycline and Artemisinin in Plasmodium falciparum

Ulrike Sponer, Somsak Prajakwong, G Wiedermann, Herwig Kollaritsch, Gunther Wernsdorfer, Walther H. Wernsdorfer

Abstract

Parallel in vitro tests, assessing the inhibition of schizont maturation, were conducted with 31 fresh isolates of Plasmodium falciparum from Thailand, using artemisinin, doxycycline, and combinations of both. The activities of artemisinin and doxycycline are obviously not correlated. Both compounds showed consistent synergism at 50% effective concentration (EC(50)), EC(90), and EC(99) levels.

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Key concepts: Artemisinin, Doxycycline, Plasmodium falciparum, In vitro, Pharmacology, Pharmacodynamics, Malaria, Biology