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2001•Infection and ImmunityOpen access

HLA-A*01-Restricted Cytotoxic T-Lymphocyte Epitope from thePlasmodium falciparumCircumsporozoite Protein

Anita Ashok Kumar, Sanjai Kumar, Thong P. Le, Scott Southwood, John Sidney, Joe Cohen, Alessandro Sette, Stephen L. Hoffman

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Abstract

Here, we report the identification of a novel CD8+ cytotoxic T-lymphocyte epitope on the Plasmodium falciparum circumsporozoite protein (3D7; amino acids 310 to 319 [EPSDKHIKEY]) that is restricted by HLA-A*01 and is recognized by human volunteers immunized with irradiated P. falciparum sporozoites. HLA-A*01 is the second most common HLA allele among Caucasians.

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What this paper is about

Here, we report the identification of a novel CD8+ cytotoxic T-lymphocyte epitope on the Plasmodium falciparum circumsporozoite protein (3D7; amino acids 310 to 319 [EPSDKHIKEY]) that is restricted by HLA-A*01 and is recognized by human volunteers immunized with irradiated P. falciparum sporozoites. HLA-A*01 is the second most common HLA allele among Caucasians.

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Available abstract

Here, we report the identification of a novel CD8+ cytotoxic T-lymphocyte epitope on the Plasmodium falciparum circumsporozoite protein (3D7; amino acids 310 to 319 [EPSDKHIKEY]) that is restricted by HLA-A*01 and is recognized by human volunteers immunized with irradiated P. falciparum sporozoites. HLA-A*01 is the second most common HLA allele among Caucasians.

Key concepts: Circumsporozoite protein, Plasmodium falciparum, Biology, Epitope, Cytotoxic T cell, Virology, Human leukocyte antigen, CD8

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