2003•Biochemical and Biophysical Research CommunicationsRequires access

Structure-based design of aliskiren, a novel orally effective renin inhibitor

Jeanette Marjorie Wood, Jürgen Maibaum, Joseph Rahuel, Markus G. Grütter, Nissim-Claude Cohen, Vittorio Rasetti, Heinrich Rüger, Richard Göschke, Stefan Stutz, Walter Fuhrer, Walter Schilling, Pascal Rigollier, Yasuchika Yamaguchi, Frédéric Cumin, Hans-Peter Baum, Christian Schnell, Peter Herold, Robert Mah, Chris Jensen, Eoin T O'Brien, Alice V. Stanton, Martin P. Bedigian

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Key concepts: Aliskiren, Renin inhibitor, Renin–angiotensin system, Pharmacology, Pharmacokinetics, In vivo, Medicine, Plasma renin activity