2005•Antimicrobial Agents and ChemotherapyOpen access

Dexamethasone Attenuates Staphylococcal Enterotoxin B-Induced Hypothermic Response and Protects Mice from Superantigen-Induced Toxic Shock

Teresa Krakauer, Marilyn Buckley

Abstract

The superantigenic staphylococcal enterotoxins are important virulence factors and contribute to various diseases, including food poisoning and toxic shock. Dexamethasone, an anti-inflammatory agent, attenuated staphylococcal enterotoxin B (SEB)-induced hypothermia and serum proinflammatory cytokines and improved survival from 0% to 86% in a lethal mouse model of SEB-mediated shock.

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Available abstract

Key concepts: Superantigen, Enterotoxin, Toxic shock syndrome, Proinflammatory cytokine, Dexamethasone, Microbiology, Virulence, Toxin