1972•Acta Pathologica JaponicaRequires access

CHRONIC MYELOGENOUS LEUKEMIA IN RATS FED 2,7‐DIACETYLAMINOFLUORENE

Shojiro Takayama, Takashi Yamada, Shoji Kamata

Abstract

We originally attempted to induce a gastric carcinoma in 327 female rats by the oral administration of 2,7‐dlacetylaminofluorene. Gastric carcinoma, however, did not appear, while leukemia was found In 31 cases (9.5%). Chronic myelogenous leukemia was encountered in 29 cases (8.9%). This leukemia in rats morphologically resembles chronic myelogenous leukemia in man.

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Key concepts: Chronic myelogenous leukemia, Leukemia, Medicine, Pathology, Internal medicine