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2013•South African Journal of ChemistryOpen access

Microwave-Assisted Synthesis of Some 1H-1,2,4-Triazol-3-one Derivatives

Nesrin Karaali, Emre Menteşe, FY Imaz, Asu Usta, Bahittin Kahveci

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Abstract

4-Amino-5-(methyl/ethyl)-2,4-dihydro-3H-1,2,4-triazol-3-one were synthesized from the reaction of (methyl/ethyl)-ester ethoxycarbonyl hydrazone with hydrazine hydrate and then, converted to corresponding Schiff bases using 9H-fluorene- 3-carbaldehyde. Ester, hydrazide and oxadiazole derivatives were synthesized starting from Schiff bases in three steps. All reactions occurred under conventional conditions and microwave irradiation. The obtained results were compared. KEYWORDS  Triazole, oxadiazole, hydrazine hydrate, microwave irradiation.

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What this paper is about

4-Amino-5-(methyl/ethyl)-2,4-dihydro-3H-1,2,4-triazol-3-one were synthesized from the reaction of (methyl/ethyl)-ester ethoxycarbonyl hydrazone with hydrazine hydrate and then, converted to corresponding Schiff bases using 9H-fluorene- 3-carbaldehyde. Ester, hydrazide and oxadiazole derivatives were synthesized starting from Schiff bases in three steps. All reactions occurred under conventional conditions and microwave irradiation. The obtained results were compared. KEYWORDS  Triazole, oxadiazole, hydrazine hydrate, microwave irradiation.

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Available abstract

4-Amino-5-(methyl/ethyl)-2,4-dihydro-3H-1,2,4-triazol-3-one were synthesized from the reaction of (methyl/ethyl)-ester ethoxycarbonyl hydrazone with hydrazine hydrate and then, converted to corresponding Schiff bases using 9H-fluorene- 3-carbaldehyde. Ester, hydrazide and oxadiazole derivatives were synthesized starting from Schiff bases in three steps. All reactions occurred under conventional conditions and microwave irradiation. The obtained results were compared. KEYWORDS  Triazole, oxadiazole, hydrazine hydrate, microwave irradiation.

Key concepts: Chemistry, Hydrazine (antidepressant), Hydrazide, Hydrate, Oxadiazole, Hydrazone, Microwave irradiation, 1,2,4-Triazole

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