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Bleomycin in combination chemotherapy of metastatic wilms tumor: A late recurrent case, refractory to conventional therapy

Tomas Kisielius, Adrian Bianco, John M. Merrill, Samuel G. Taylor, William D. DeWys

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Abstract

A patient with a late recurrence (13 years) of Wilms tumor is presented. After relapse with conventional chemotherapy, an objective partial remission was obtained with bleomycin, vinblastine, cyclophosphamide, and cis-platinum. Stable disease was noted when bleomycin was withheld. Bleomycin in this combination appeared to effect a good response, and further studies of chemotherapy of Wilms tumor should include bleomycin in combination with other active agents.

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What this paper is about

A patient with a late recurrence (13 years) of Wilms tumor is presented. After relapse with conventional chemotherapy, an objective partial remission was obtained with bleomycin, vinblastine, cyclophosphamide, and cis-platinum. Stable disease was noted when bleomycin was withheld. Bleomycin in this combination appeared to effect a good response, and further studies of chemotherapy of Wilms tumor should include bleomycin in combination with other active agents.

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OpenAlex reports 5 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

A patient with a late recurrence (13 years) of Wilms tumor is presented. After relapse with conventional chemotherapy, an objective partial remission was obtained with bleomycin, vinblastine, cyclophosphamide, and cis-platinum. Stable disease was noted when bleomycin was withheld. Bleomycin in this combination appeared to effect a good response, and further studies of chemotherapy of Wilms tumor should include bleomycin in combination with other active agents.

Key concepts: Bleomycin, Medicine, Vinblastine, Chemotherapy, Cyclophosphamide, Wilms' tumor, Refractory (planetary science), Combination chemotherapy

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Bleomycin in combination chemotherapy of metastatic wilms tumor: A late recurrent case, refractory to conventional therapy — Research Paper | ScholarLens