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1969•Acta Pathologica JaponicaRequires access

LETTERER‐SIWE DISEASE AND EOSINOPHILIC GRANULOMA CASE REPORT INCLUDING THE ULTRASTRUCTURAL FINDINGS OF THE HISTIOCYTES PROLIFERATING IN THESE DISORDERS

Yōichirō Kondō, Hisao Tomioka, M Itoh

Open publisher page 16 citations

Abstract

Two autopsy cases of Letterer‐Siwe disease and a bone lesion of eosinophilic granuloma obtained at surgical operation have been presented. Electron microscopic examination of the skin lesion of one case of Letterer‐Siwe disease revealed that the histiocytes accumulating in the dermis contained characteristic Langerhans cell granules. The number of granules was variable due probably to cell maturation or activity. Similar histiocytes containing the Langerhans cell granules were observed in the bone lesion of eosinophilic granuloma. From this, it is assumed that the histocytes in these disorders have a common functional property. In addition, the possible origin of the epidermal Langerhans cell was also discussed in relation to these findings.

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Two autopsy cases of Letterer‐Siwe disease and a bone lesion of eosinophilic granuloma obtained at surgical operation have been presented. Electron microscopic examination of the skin lesion of one case of Letterer‐Siwe disease revealed that the histiocytes accumulating in the dermis contained characteristic Langerhans cell granules. The number of granules was variable due probably to cell maturation or activity. Similar histiocytes containing the Langerhans cell granules were observed in the bone lesion of eosinophilic granuloma. From this, it is assumed that the histocytes in these disorders have a common functional property. In addition, the possible origin of the epidermal Langerhans cell was also discussed in relation to these findings.

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OpenAlex reports 16 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Two autopsy cases of Letterer‐Siwe disease and a bone lesion of eosinophilic granuloma obtained at surgical operation have been presented. Electron microscopic examination of the skin lesion of one case of Letterer‐Siwe disease revealed that the histiocytes accumulating in the dermis contained characteristic Langerhans cell granules. The number of granules was variable due probably to cell maturation or activity. Similar histiocytes containing the Langerhans cell granules were observed in the bone lesion of eosinophilic granuloma. From this, it is assumed that the histocytes in these disorders have a common functional property. In addition, the possible origin of the epidermal Langerhans cell was also discussed in relation to these findings.

Key concepts: Histiocyte, Eosinophilic granuloma, Pathology, Dermis, Langerhans cell, Lesion, Eosinophilic, Medicine

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LETTERER‐SIWE DISEASE AND EOSINOPHILIC GRANULOMA CASE REPORT INCLUDING THE ULTRASTRUCTURAL FINDINGS OF THE HISTIOCYTES PROLIFERATING IN THESE DISORDERS — Research Paper | ScholarLens