2003•Antimicrobial Agents and ChemotherapyOpen access

Discordant Resistance to Kanamycin and Amikacin in Drug-Resistant Mycobacterium tuberculosis

Annika Krüüner, Pontus Juréen, Klavdia Levina, Solomon Ghebremichael, Sven Hoffner

Abstract

It is generally thought that there is full cross-resistance in Mycobacterium tuberculosis between the aminoglycoside drugs kanamycin and amikacin. However, kanamycin resistance and amikacin susceptibility were seen in 43 of 79 (54%) multidrug-resistant Estonian isolates, indicating that there might be a need to test the resistance of M. tuberculosis isolates to both drugs.

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Key concepts: Amikacin, Kanamycin, Mycobacterium tuberculosis, Aminoglycoside, Microbiology, Tuberculosis, Drug resistance, Medicine