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2002•Tissue AntigensRequires access

Novel HLA‐B alleles formed by an inter‐locus recombination with HLA‐C, HLA‐B*0713 and B*6702

Noriko Steiner, L.A. Baldassarre, Ruth P. Koester, Julian Ng, Robert J. Hartzman, C K Hurley

Open publisher page 12 citations

Abstract

This paper describes two novel HLA-B locus alleles. B*0713 appears to have resulted from an interlocus recombinational event which inserted a sequence from an HLA-C allele into B*0702. This event altered a significant portion of the alpha-1 domain alpha helix. B*6702 shares much of its exon 2 sequence with B*0713 but is identical in exon 3 to several HLA-B locus alleles including B*67012.

About this research paper

What this paper is about

This paper describes two novel HLA-B locus alleles. B*0713 appears to have resulted from an interlocus recombinational event which inserted a sequence from an HLA-C allele into B*0702. This event altered a significant portion of the alpha-1 domain alpha helix. B*6702 shares much of its exon 2 sequence with B*0713 but is identical in exon 3 to several HLA-B locus alleles including B*67012.

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OpenAlex reports 12 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

This paper describes two novel HLA-B locus alleles. B*0713 appears to have resulted from an interlocus recombinational event which inserted a sequence from an HLA-C allele into B*0702. This event altered a significant portion of the alpha-1 domain alpha helix. B*6702 shares much of its exon 2 sequence with B*0713 but is identical in exon 3 to several HLA-B locus alleles including B*67012.

Key concepts: Allele, Locus (genetics), Genetics, Exon, HLA-A, Biology, Human leukocyte antigen, HLA-B

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Novel HLA‐B alleles formed by an inter‐locus recombination with HLA‐C, HLA‐B*0713 and B*6702 — Research Paper | ScholarLens