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1997•Journal of Neurology Neurosurgery & PsychiatryOpen access

Cerebral blood flow and cerebrovascular response to acetazolamide in patients with chronic alcoholism

Mitsuhiro Oishi, Yoko Mochizuki, T Takasu

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Abstract

Cerebral blood flow and cerebrovascular response to acetazolamide were studied in 12 patients with chronic alcoholism and 12 age matched healthy controls. Blood flows in the cerebral cortex, thalamus, and putamen were significantly lower in the chronic alcoholic group than in the healthy control group. The increase in blood flow caused by acetazolamide did not show any significant difference between the two groups. These findings suggest that the decreased cerebral blood flow in chronic alcoholism is due to decreased cerebral metabolism.

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What this paper is about

Cerebral blood flow and cerebrovascular response to acetazolamide were studied in 12 patients with chronic alcoholism and 12 age matched healthy controls. Blood flows in the cerebral cortex, thalamus, and putamen were significantly lower in the chronic alcoholic group than in the healthy control group. The increase in blood flow caused by acetazolamide did not show any significant difference between the two groups. These findings suggest that the decreased cerebral blood flow in chronic alcoholism is due to decreased cerebral metabolism.

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Available abstract

Cerebral blood flow and cerebrovascular response to acetazolamide were studied in 12 patients with chronic alcoholism and 12 age matched healthy controls. Blood flows in the cerebral cortex, thalamus, and putamen were significantly lower in the chronic alcoholic group than in the healthy control group. The increase in blood flow caused by acetazolamide did not show any significant difference between the two groups. These findings suggest that the decreased cerebral blood flow in chronic alcoholism is due to decreased cerebral metabolism.

Key concepts: Acetazolamide, Cerebral blood flow, Medicine, Chronic alcoholism, Internal medicine, Blood flow, Thalamus, Putamen

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