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Hemoglobin Thailand [α 56 (E 5) Lys→Thr]: A New Abnormal Human Hemoglobin

S. Pootrakul, Dawan Boonyarat, B. Kematom, S. Suanpan, P Wasi

Open publisher page 30 citations

Abstract

A healthy Thai male was found to have an abnormal hemoglobin moving faster than Hb A in starch-gel electrophoresis, in addition to the normal hemoglobin constituents. The abnormal hemoglobin constituted 28% of the whole hemoglobin. The subject was asymptomatic and had normal hematologic findings. Structural characterization revealed that the amino acid substitution was alpha 56 Lys leads to Thr. This variant has never been described previously and it is named Hb Thailand.

About this research paper

What this paper is about

A healthy Thai male was found to have an abnormal hemoglobin moving faster than Hb A in starch-gel electrophoresis, in addition to the normal hemoglobin constituents. The abnormal hemoglobin constituted 28% of the whole hemoglobin. The subject was asymptomatic and had normal hematologic findings. Structural characterization revealed that the amino acid substitution was alpha 56 Lys leads to Thr. This variant has never been described previously and it is named Hb Thailand.

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OpenAlex reports 30 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

A healthy Thai male was found to have an abnormal hemoglobin moving faster than Hb A in starch-gel electrophoresis, in addition to the normal hemoglobin constituents. The abnormal hemoglobin constituted 28% of the whole hemoglobin. The subject was asymptomatic and had normal hematologic findings. Structural characterization revealed that the amino acid substitution was alpha 56 Lys leads to Thr. This variant has never been described previously and it is named Hb Thailand.

Key concepts: Hemoglobin, Hemoglobin variants, Hemoglobin electrophoresis, Asymptomatic, Hemoglobin A2, Hemoglobin A, Hemoglobin s, Amino acid substitution

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