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Parenteral Nutrition. XI. Studies with Stable and Unstable Fat Emulsions Administered Intravenously.

Robert P. Geyer, Donald M. Watkin, LeRoy W. Matthews, Frederick J. Stare

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Abstract

Both stable and unstable emulsions of fat have been administered intravenously to rats. The stable emulsions caused a moderate increase in total lipids of the spleen, liver, and lungs; whereas, a very marked increase was observed when unstable emulsions were given. Much of the increase due to the latter type of emulsion was caused by large extracellular fat globules. The removal of the excess fat in the tissues has been studied and found to be rapid in the case of stable emulsions, and slower but definite in the case of the unstable emulsions.

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What this paper is about

Both stable and unstable emulsions of fat have been administered intravenously to rats. The stable emulsions caused a moderate increase in total lipids of the spleen, liver, and lungs; whereas, a very marked increase was observed when unstable emulsions were given. Much of the increase due to the latter type of emulsion was caused by large extracellular fat globules. The removal of the excess fat in the tissues has been studied and found to be rapid in the case of stable emulsions, and slower but definite in the case of the unstable emulsions.

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Available abstract

Both stable and unstable emulsions of fat have been administered intravenously to rats. The stable emulsions caused a moderate increase in total lipids of the spleen, liver, and lungs; whereas, a very marked increase was observed when unstable emulsions were given. Much of the increase due to the latter type of emulsion was caused by large extracellular fat globules. The removal of the excess fat in the tissues has been studied and found to be rapid in the case of stable emulsions, and slower but definite in the case of the unstable emulsions.

Key concepts: Fat emulsion, Emulsion, Globules of fat, Parenteral nutrition, Chemistry, Spleen, Extracellular, Internal medicine

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