2008•HaematologicaOpen access

The IL6(-174G/C) polymorphism is a prognostic factor for survival after treatment initiation in Waldenstrom macroglobulinemia patients aged 65 years or less

Stéphanie Poulain, Isabelle Dervite, Xavier Leleu, Valérie Coiteux, Patrick Duthilleul, Pierre Morel

Abstract

Waldenstrom macroglobulinemia (WM) is characterized by the production of serum monoclonal immunoglobulin (Ig) M and by lymphoplasmacytic bone marrow infiltration.[1][1] Upregulation of interleukin 6 (IL6) has been demonstrated in WM,[2][2],[3][3] in accordance with the increased IL6 serum

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Key concepts: Waldenstrom macroglobulinemia, Macroglobulinemia, Medicine, Bone marrow, Immunoglobulin M, Monoclonal, Downregulation and upregulation, Interleukin 6