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1940•The Journal of Experimental MedicineOpen access

THE SYNERGISM OF HUMAN INFLUENZA AND CANINE DISTEMPER VIRUSES IN FERRETS

Frank L. Horsfall, Edwin H. Lennette

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Abstract

The infections produced in ferrets by human influenza virus and canine distemper virus were studied. Cross immunity and cross neutralization tests showed that these two viruses were not related antigenically. Ferrets infected with influenza virus alone rapidly produced considerable quantities of neutralizing antibodies, and after the 6th day virus was not demonstrable in their lungs. Ferrets infected with both influenza and distemper viruses simultaneously produced but small amounts of neutralizing antibody, and influenza virus persisted in undiminished concentration in their lungs throughout the course of the infection.

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The infections produced in ferrets by human influenza virus and canine distemper virus were studied. Cross immunity and cross neutralization tests showed that these two viruses were not related antigenically. Ferrets infected with influenza virus alone rapidly produced considerable quantities of neutralizing antibodies, and after the 6th day virus was not demonstrable in their lungs. Ferrets infected with both influenza and distemper viruses simultaneously produced but small amounts of neutralizing antibody, and influenza virus persisted in undiminished concentration in their lungs throughout the course of the infection.

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Available abstract

The infections produced in ferrets by human influenza virus and canine distemper virus were studied. Cross immunity and cross neutralization tests showed that these two viruses were not related antigenically. Ferrets infected with influenza virus alone rapidly produced considerable quantities of neutralizing antibodies, and after the 6th day virus was not demonstrable in their lungs. Ferrets infected with both influenza and distemper viruses simultaneously produced but small amounts of neutralizing antibody, and influenza virus persisted in undiminished concentration in their lungs throughout the course of the infection.

Key concepts: Canine distemper, Virology, Virus, Neutralization, Biology, Antibody, Neutralizing antibody, Immunity

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