2012•Critical CareOpen access

Predictive value of glial fibrillary acidic protein for prognosis in patients with moderate and severe traumatic brain injury: a systematic review and meta-analysis

Éléna Laroche, AF Turgeon, Amélie Boutin, Éric Mercier, François Lauzier, Ryan Zarychanski, Lynne Moore, J Granton, Patrick Michel Archambault, François Lamontagne, François Rousseau, France Légaré, Ed Randell, J.‐M. Lapointe, Joyca P. W. Lacroix, Dean A. Fergusson

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Abstract

Biomarkers have been proposed as potential prognostic indicators following a traumatic brain injury (TBI). Among those, glial fibrillary acidic protein (GFAP) has been one of the most studied. The objective of this study was to assess the prognostic value of GFAP levels in patients with moderate to severe TBI.

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Key concepts: Glial fibrillary acidic protein, Traumatic brain injury, Medicine, Predictive value, Internal medicine, Pathology, Immunohistochemistry, Psychiatry