2013•Chemical CommunicationsOpen access

Different thermodynamic signatures for DNA minor groove binding with changes in salt concentration and temperature

Shuo Wang, Arvind Kumar, Karl W. Aston, Binh N. Nguyen, James K. Bashkin, David W. Boykin, W. David Wilson

Abstract

The effects of salt concentration and temperature on the thermodynamics of DNA minor groove binding have quite different signatures: binding enthalpy is salt concentration independent but temperature dependent. Conversely, binding free energy is salt dependent but essentially temperature independent through enthalpy-entropy compensation.

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Key concepts: Minor groove, Enthalpy, Chemistry, Thermodynamics, Entropy (arrow of time), Salt (chemistry), Binding energy, DNA