2006•The Journal of PhysiologyOpen access

Prestin and the cochlear amplifier

Peter Dallos, Jing Zheng, Mary Ann Cheatham

Abstract

In non-mammalian, hair cell-bearing sense organs amplification is associated with mechano-electric transducer channels in the stereovilli (commonly called stereocilia). Because mammals possess differentiated outer hair cells (OHC), they also benefit from a novel electromotile process, powered by the motor protein, prestin. Here we consider new work pertaining to this protein and its potential role as the mammalian cochlear amplifier.

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Key concepts: Prestin, Stereocilia (inner ear), Motor protein, Outer hair cells, Cochlea, Hair cell, Neuroscience, Cell biology