2004•Journal of Clinical MicrobiologyOpen access

DNA Polymorphism Assay Distinguishes Isolates ofLeishmania donovaniThat Cause Kala-Azar from Those That Cause Post-Kala-Azar Dermal Leishmaniasis in Humans

Sreenivas Gannavaram, B. V. Subba Raju, Ruchi Singh, Angamuthu Selvapandiyan, Robert Duncan, Dwijen Sarkar, Hira L. Nakhasi, Poonam Salotra

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Abstract

Leishmania donovani in India causes visceral infection (kala-azar) and dermal infection (post-kala-azar dermal leishmaniasis). We report here the identification of polymorphism in a well-defined genetic locus among the Leishmania parasites causing the visceral and dermal manifestations, in a comparison of 15 post-kala-azar dermal leishmaniasis and 12 kala-azar patient isolates.

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Key concepts: Leishmania donovani, Visceral leishmaniasis, Leishmaniasis, Biology, Leishmania, Cutaneous leishmaniasis, Virology, Kinetoplastida