2003•Journal of VirologyOpen access
High Circulating Frequencies of Tumor Necrosis Factor Alpha- and Interleukin-2-Secreting Human T-Lymphotropic Virus Type 1 (HTLV-1)-Specific CD4+T Cells in Patients with HTLV-1-Associated Neurological Disease
Peter Goon, Tadahiko Igakura, Emmanuel Hanon, Angelina J. Mosley, Becca Asquith, Keith G. Gould, Graham P. Taylor, Jonathan Weber, Charles R. M. Bangham
Open full text 60 citations
Abstract
Significantly higher frequencies of tumor necrosis factor alpha- and interleukin-2-secreting human T-lymphotropic virus type 1 (HTLV-1)-specific CD4(+) T cells were present in the peripheral blood mononuclear cells of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients than in those of asymptomatic carriers with similar provirus loads. The data suggest that HTLV-1-specific CD4(+) T cells play a role in the pathogenesis of HAM/TSP.