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Assessment of Left Ventricular Dyssynchrony in Patients With Heart Failure and Normal QRS Duration

Vidya Narayan, Padmini Varadarajan, Ramdas G. Pai

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Abstract

Cardiac resynchronization therapy (CRT) is an important component of heart failure therapy in patients with a left ventricular ejection fraction <35%, class III or ambulatory class IV symptoms, and a QRS duration >120 ms. The QRS duration criterion for patient selection is imperfect. About 30% of patients with an increased QRS duration are nonresponders to CRT and many with a normal QRS duration with mechanical dyssynchrony respond to CRT. The authors review the currently available echocardiographic tools for the assessment of ventricular dyssynchrony in patients with heart failure.

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What this paper is about

Cardiac resynchronization therapy (CRT) is an important component of heart failure therapy in patients with a left ventricular ejection fraction <35%, class III or ambulatory class IV symptoms, and a QRS duration >120 ms. The QRS duration criterion for patient selection is imperfect. About 30% of patients with an increased QRS duration are nonresponders to CRT and many with a normal QRS duration with mechanical dyssynchrony respond to CRT. The authors review the currently available echocardiographic tools for the assessment of ventricular dyssynchrony in patients with heart failure.

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Available abstract

Cardiac resynchronization therapy (CRT) is an important component of heart failure therapy in patients with a left ventricular ejection fraction <35%, class III or ambulatory class IV symptoms, and a QRS duration >120 ms. The QRS duration criterion for patient selection is imperfect. About 30% of patients with an increased QRS duration are nonresponders to CRT and many with a normal QRS duration with mechanical dyssynchrony respond to CRT. The authors review the currently available echocardiographic tools for the assessment of ventricular dyssynchrony in patients with heart failure.

Key concepts: Medicine, QRS complex, Cardiology, Heart failure, Ejection fraction, Internal medicine, Cardiac resynchronization therapy, Ventricular dyssynchrony

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