1988•MicrobiologyRequires access

Mixed-Ligand Complexes of Platinum(II) as Curing Agents for pBR322 and pBR329 (ColE1) Plasmids in Escherichia coli

V. V. Lakshmi, Pennathur Sridhar, Badar Taqui Khan, Hanmanlu Polasa

Abstract

The mixed-ligand complexes of platinum(II) [Pt(Gly)(uracil)Cl2].H2O and [Pt(His)(adenine)]-Cl.2H2O eliminated multicopy plasmids with the ColE1 origin of replication in Escherichia coli with 100% frequency. However, plasmids of the IncF1, H1 and X groups were totally refractory to these agents under similar conditions.

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Key concepts: ColE1, Plasmid, PBR322, Escherichia coli, Platinum, Chemistry, Ligand (biochemistry), DNA