1995•Journal of VirologyOpen access

The leader polypeptide of Theiler's virus is essential for neurovirulence but not for virus growth in BHK cells

M A Calenoff, Cyrus Badshah, M. C. Dal Canto, Howard L. Lipton, M K Rundell

Abstract

A leader polypeptide of unknown function is encoded by cardioviruses, such as Theiler's murine encephalomyelitis virus. Although the deletion of this polypeptide has little effect on the growth of parental GDVII virus in baby hamster kidney (BHK) cells, the mutant virus is completely attenuated and fails to kill mice receiving intracerebral inoculations of high doses of the virus.

About this research paper

What this paper is about

Why it matters

OpenAlex reports 39 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Key concepts: Baby hamster kidney cell, Biology, Virology, Virus, Hamster, Mutant, Molecular biology, Genetics