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2004•Alcohol and AlcoholismRequires access

DIMINISHED CD4+ T CELL SURFACE CCR5 EXPRESSION IN ALCOHOLIC PATIENTS

Pascal Perney, Pierre Portalès, Jacques Clot, F Blanc, Pierre Corbeau

Open publisher page 5 citations

Abstract

AIMS: The C-C chemokine receptors, particularly the CCR5, appeared to play an important role in T cell-mediated inflammatory reactions. The aim of our study was to assess the impact of chronic alcohol consumption on the in vivo CCR5 expression. METHODS: Fourteen alcoholic men hospitalized for a detoxification programme were prospectively included and compared with 49 age-matched controls. RESULTS: The CD4(+) T cell surface CCR5 densities were drastically lower in alcoholic patients [mean, 5319 molecules/cell; 95% confidence interval (CI) 4477-6162] as compared with CCR5 densities of the controls (10 944 molecules/cell [CI 9929-11959]; P < 10(-4)). CONCLUSIONS: Chronic alcohol consumption is associated with a significant decrease of CCR5 expression, which could favour Th1/Th2 imbalance.

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What this paper is about

AIMS: The C-C chemokine receptors, particularly the CCR5, appeared to play an important role in T cell-mediated inflammatory reactions. The aim of our study was to assess the impact of chronic alcohol consumption on the in vivo CCR5 expression. METHODS: Fourteen alcoholic men hospitalized for a detoxification programme were prospectively included and compared with 49 age-matched controls. RESULTS: The CD4(+) T cell surface CCR5 densities were drastically lower in alcoholic patients [mean, 5319 molecules/cell; 95% confidence interval (CI) 4477-6162] as compared with CCR5 densities of the controls (10 944 molecules/cell [CI 9929-11959]; P < 10(-4)). CONCLUSIONS: Chronic alcohol consumption is associated with a significant decrease of CCR5 expression, which could favour Th1/Th2 imbalance.

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Available abstract

AIMS: The C-C chemokine receptors, particularly the CCR5, appeared to play an important role in T cell-mediated inflammatory reactions. The aim of our study was to assess the impact of chronic alcohol consumption on the in vivo CCR5 expression. METHODS: Fourteen alcoholic men hospitalized for a detoxification programme were prospectively included and compared with 49 age-matched controls. RESULTS: The CD4(+) T cell surface CCR5 densities were drastically lower in alcoholic patients [mean, 5319 molecules/cell; 95% confidence interval (CI) 4477-6162] as compared with CCR5 densities of the controls (10 944 molecules/cell [CI 9929-11959]; P < 10(-4)). CONCLUSIONS: Chronic alcohol consumption is associated with a significant decrease of CCR5 expression, which could favour Th1/Th2 imbalance.

Key concepts: Internal medicine, Chemokine, Receptor, Confidence interval, Alcohol consumption, Medicine, Endocrinology, Cell

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