Establishment of and Recovery from Damage Checkpoint Requires Sequential Interactions of Crb2 with Protein Kinases Rad3, Chk1, and Cdc2

Checkpoint pathways ensure that the progression of thecell cycle is restrained while repair is carried out on chromosomes that are damaged by UV or ionized radiation(Hartwell and Weinert 1989). A number of gene productsneeded for establishing the damage checkpoint have beenidentified. Importantly, most checkpoint proteins appearto be conserved through evolution (Elledge 1996). In thispaper, we discuss control of the damage checkpoint in thefission yeast Schizosaccharomyces pombe, an excellentmodel organism for analyses of cell cycle and checkpointcontrol...