A Case of Lymphocytic Infundibuloneurohypophysitis Along with Central Diabetes Insipidus, and this Improved with Conservative Care

Idiopathic central diabetes insipidus is most likely to occur in young patients who have a clinical history of autoimmune disease.The presentation of clinical findings such as central diabetes insipidus and pituitary stalk thickening on sellar magnetic resonance imaging (MRI) in a young women would strongly suggest lymphocytic hypophysitis, which is a rare inflammatory process involving the pituitary stalk and the pituitary gland, yet this disease can sometimes regress.We describe here a young woman with lymphocytic hypophysitis.She suffered from an abrupt onset of central diabetes insipidus.Sellar MRI showed thickening of pituitary stalk and loss of high signal of normal neurohypophysis on T1-weighted image.Combind pituitary stimuation test showed a blunted response of GH.To avoid the potential detrimental complications of invasive diagnostic procedures for testing the pituitary function in a fertile unmarried young woman, we chose close clinical and radiologic follow-up in the proper clinical context.The requirement for DDAVP was slightly decreased over time and the MR imaging obtained serially for 6 months revealed spontaneous partial regression of the pituitary lesion.(