2010•Mini-Reviews in Medicinal ChemistryRequires access

Recent Advances in the Development of Small-molecule CCR5 Inhibitors for HIV

Tao Liu, Zhiyong Weng, Xiaowu Dong, Yongzhou Hu

Abstract

CCR5 (C-C chemokine receptor type 5) is a chemokine receptor that has been identified as a major HIV co-receptor in viral entry and therefore is a highly validated target for the development of new anti-HIV drugs. Here, we discuss the insights gained so far relevant to the development of small-molecule CCR5 inhibitors for the treatment of HIV, and highlight small-molecule CCR5 inhibitors that are currently under preclinical and clinical trials.

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Key concepts: CCR5 receptor antagonist, Maraviroc, Small molecule, Chemokine receptor CCR5, Human immunodeficiency virus (HIV), Chemokine receptor, Chemokine, Receptor