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1999•European Journal of ImmunogeneticsRequires access

The BglII polymorphism of the human prolactin gene lies within intron C and can be detected by PCR/RFLP

Adam Stevens, Ali H. Hajeer, S. John, Wendy Thomson, Jane Worthington, J.R. Davis, Wer Ollier

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Abstract

Prolactin has been shown to be active as an immunomodulatory hormone and is therefore of potential importance in disease progression and development. Any polymorphism in the gene and regulatory sequences may prove useful for disease association studies. A Bg/II polymorphism has been previously detected within the prolactin gene region. We have mapped this polymorphism to intron C and detected the base mutation that causes it. We have also developed a PCR-RFLP method to genotype individuals.

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What this paper is about

Prolactin has been shown to be active as an immunomodulatory hormone and is therefore of potential importance in disease progression and development. Any polymorphism in the gene and regulatory sequences may prove useful for disease association studies. A Bg/II polymorphism has been previously detected within the prolactin gene region. We have mapped this polymorphism to intron C and detected the base mutation that causes it. We have also developed a PCR-RFLP method to genotype individuals.

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OpenAlex reports 5 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Prolactin has been shown to be active as an immunomodulatory hormone and is therefore of potential importance in disease progression and development. Any polymorphism in the gene and regulatory sequences may prove useful for disease association studies. A Bg/II polymorphism has been previously detected within the prolactin gene region. We have mapped this polymorphism to intron C and detected the base mutation that causes it. We have also developed a PCR-RFLP method to genotype individuals.

Key concepts: Biology, Restriction fragment length polymorphism, Intron, Genetics, Genotype, Gene, Polymorphism (computer science), Prolactin

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The BglII polymorphism of the human prolactin gene lies within intron C and can be detected by PCR/RFLP — Research Paper | ScholarLens