2005•Journal of BacteriologyOpen access

Rv2358 and FurB: Two Transcriptional Regulators from Mycobacterium tuberculosis Which Respond to Zinc

Fabio Canneva, Manuela Branzoni, Giovanna Riccardi, Roberta Provvedi, Anna Milano

Abstract

In a previous work, we demonstrated that the Mycobacterium tuberculosis Rv2358-furB operon is induced by zinc. In this study, the orthologous genes from Mycobacterium smegmatis mc(2)155 were inactivated and mutants analyzed. Rv2358 protein was purified and found to bind upstream of the Rv2358 gene. Binding was inhibited by Zn(2+) ions.

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Key concepts: Biology, Mycobacterium tuberculosis, Microbiology, Tuberculosis, Bacterial protein, Zinc, Mycobacterium, Bacteria