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2001•Pediatric Hematology and OncologyRequires access

TRANSPLANTED PERIPHERAL BLOOD STEM CELLS, MOBILIZED BY CHEMOTHERAPY ALONE, CAN INDUCE PERSISTENT HEMATOPOIESIS IN CHILDREN WITH ACUTE LEUKEMIA

Tooru Kudoh, Shizue Katoh, Nobuhiro Suzuki, Takanori Oda, Shunzo Chiba, Junichi Miura

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Abstract

Three patients with leukemia were transplanted with peripheral blood stem cells mobilized by intensification or maintenance chemotherapy alone. They maintained persistent reconstituted hematopoiesis for at least 9 years. The experience provides evidence that long-term marrow repopulating cells can be mobilized into the blood to an adequate repopulating extent by chemotherapy alone.

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What this paper is about

Three patients with leukemia were transplanted with peripheral blood stem cells mobilized by intensification or maintenance chemotherapy alone. They maintained persistent reconstituted hematopoiesis for at least 9 years. The experience provides evidence that long-term marrow repopulating cells can be mobilized into the blood to an adequate repopulating extent by chemotherapy alone.

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Available abstract

Three patients with leukemia were transplanted with peripheral blood stem cells mobilized by intensification or maintenance chemotherapy alone. They maintained persistent reconstituted hematopoiesis for at least 9 years. The experience provides evidence that long-term marrow repopulating cells can be mobilized into the blood to an adequate repopulating extent by chemotherapy alone.

Key concepts: Haematopoiesis, Medicine, Peripheral Blood Stem Cells, Stem cell, Chemotherapy, Leukemia, Peripheral blood, Immunology

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TRANSPLANTED PERIPHERAL BLOOD STEM CELLS, MOBILIZED BY CHEMOTHERAPY ALONE, CAN INDUCE PERSISTENT HEMATOPOIESIS IN CHILDREN WITH ACUTE LEUKEMIA — Research Paper | ScholarLens