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Spontaneous Ovarian Choriocarcinoma, Yolk Sac Carcinoma, and Teratoma in B6C3F1 Mice: A Case Report

Chris Frith, Mark Gordon Evans

Abstract

Three ovarian neoplasms (choriocarcinoma, yolk sac carcinoma, and teratoma) were diagnosed in a 2 yr carcinogenicity study involving B6C3F1 mice. The yolk sac carcinoma and the teratoma occurred in opposite ovaries of a single female mouse that was sacrificed in extremis on study day 725. The choriocarcinoma occurred in a female mouse that was sacrificed in extremis on study day 565. These neoplasms were considered to be spontaneous in origin.

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Key concepts: Yolk sac, Choriocarcinoma, Teratoma, Immature teratoma, Carcinoma, Ovarian Teratoma, Ovary, Pathology