2006•Marine DrugsOpen access

The Structural Basis and Functional Consequences of Interactions Between Tetrodotoxin and Voltage-Gated Sodium Channels

Shana L. Geffeney, Cody Ruben

Abstract

Tetrodotoxin (TTX) is a highly specific blocker of voltage-gated sodium channels. The dissociation constant of block varies with different channel isoforms. Until recently, channel resistance was thought to be primarily imparted by amino acid substitutions at a single position in domain I. Recent work reveals a novel site for tetrodotoxin resistance in the P-region of domain IV.

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Key concepts: Tetrodotoxin, Sodium channel, Chemistry, Basis (linear algebra), Sodium, Voltage, Biophysics, Biology