2002•Journal of Clinical MicrobiologyOpen access
Emergence of an Influenza B Virus with Antigenic Change
Naoko Nakagawa, Souichi Nukuzuma, Shigekazu Haratome, Shosan Go, Toshimasa Nakagawa, Kozaburo Hayashi
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Abstract
Influenza B virus Yamagata group strains, isolated in the 2000 to 2001 influenza epidemic season, reacted poorly to the polyclonal ferret sera prepared against strains isolated earlier. The results of genetic analysis clarified that a point mutation of the nucleotide at position 126 in the HA1 region and the corresponding one-amino-acid substitution altered viral antigenicity.