2002•Clinical and Vaccine ImmunologyOpen access

Influence of Antimalarial Treatment on Acquisition of Immunity in Plasmodium berghei NK65 Malaria

Ton That Ai Long, Shusuke Nakazawa, Maria Cecilia Huaman, Hiroji Kanbara

Abstract

Antimalarial treatments during primary Plasmodium berghei NK65 infection in BALB/c mice influenced the acquisition of protective immunity against reinfection. Among subcurative treatments, lower doses better enable mice to acquire protective immunity than do higher doses. Eradication of parasites from the start of infection did not promote protective immunity.

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Key concepts: Plasmodium berghei, Malaria, Immunity, Plasmodium (life cycle), Immunology, Biology, Virology, Immune system