2010•Advanced MaterialsRequires access

Chemical Nanosensors Based on Composite Molecularly Imprinted Polymer Particles and Surface‐Enhanced Raman Scattering

Marc Bompart, Yannick De Wilde, Karsten Haupt

Abstract

Chemical nanosensors with a submicrometer core–shell composite design, based on a polymer core, a molecularly imprinted polymer (MIP) shell for specific analyte recognition, and an interlayer of gold nanoparticles for signal amplification, are described. SERS measurements on single nanosensors yield detection limits of 10−7 M for the β-blocker propranolol, several orders of magnitude lower than on plain MIP spheres.

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Key concepts: Nanosensor, Molecularly imprinted polymer, Materials science, Nanotechnology, Nanoparticle, Polymer, Composite number, Analyte