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1985•FEMS Microbiology LettersRequires access

Streptomycin biosynthesis inStreptomyces griseusI. Characterization of streptomycin-idiotrophic mutants

Jürgen Distler, K. Klier, Wolfgang Piendl, Oleg Werbitzky, A. Böck, G. Kresze, Wolfgang Piepersberg

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Abstract

A total of 16 idiotrophic mutants unable to produce the aminoglycoside antibiotic streptomycin (smi) were isolated from Streptomyces griseus N2-3-11. Cosynthesis of streptomycin, its formation from various precursors and analysis of accumulated intermediates allowed grouping of the mutants in 3 classes, blocked: (I) in the first transamination step of the streptidine pathway; (II) in later steps of the streptidine pathway; or (III) outside streptidine biosynthesis.

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A total of 16 idiotrophic mutants unable to produce the aminoglycoside antibiotic streptomycin (smi) were isolated from Streptomyces griseus N2-3-11. Cosynthesis of streptomycin, its formation from various precursors and analysis of accumulated intermediates allowed grouping of the mutants in 3 classes, blocked: (I) in the first transamination step of the streptidine pathway; (II) in later steps of the streptidine pathway; or (III) outside streptidine biosynthesis.

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Available abstract

A total of 16 idiotrophic mutants unable to produce the aminoglycoside antibiotic streptomycin (smi) were isolated from Streptomyces griseus N2-3-11. Cosynthesis of streptomycin, its formation from various precursors and analysis of accumulated intermediates allowed grouping of the mutants in 3 classes, blocked: (I) in the first transamination step of the streptidine pathway; (II) in later steps of the streptidine pathway; or (III) outside streptidine biosynthesis.

Key concepts: Streptomyces griseus, Streptomycin, Biosynthesis, Mutant, Aminoglycoside, Transamination, Streptomycetaceae, Streptomyces

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