Daily Variation in Concentration of Plasma Corticosteroid in Hypophysectomized Rats
ALBERT H. MEIER
Abstract
ALBERT H. MEIER
Abstract
A daily variation in the concentration of plasma corticosteroid hormone is present in hypophysectomized rats implanted with pellets of adrenocorticotropic hormone (ACTH) and thyroxine. Although ACTH is necessary to maintain a functional adrenal, and thyroxine is required to permit the expression of the plasma corticosteroid rhythm, a normal daily variation in plasma corticosteroid concentration does not appear to depend on the periodic release of pituitary hormones.
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A daily variation in the concentration of plasma corticosteroid hormone is present in hypophysectomized rats implanted with pellets of adrenocorticotropic hormone (ACTH) and thyroxine. Although ACTH is necessary to maintain a functional adrenal, and thyroxine is required to permit the expression of the plasma corticosteroid rhythm, a normal daily variation in plasma corticosteroid concentration does not appear to depend on the periodic release of pituitary hormones.
Key concepts: Internal medicine, Endocrinology, Corticosteroid, Adrenocorticotropic hormone, Hormone, Hypophysectomy, Pituitary gland, Plasma concentration