1987•Antimicrobial Agents and ChemotherapyOpen access
Pharmacokinetics of cefoperazone and tobramycin alone and in combination
B. Joseph Guglielmo, John F. Flaherty, T M Woods, Greg Lafollette, John G. Gambertoglio
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Abstract
Certain beta-lactams have been shown to increase the clearance of tobramycin. We evaluated the pharmacokinetics of cefoperazone and tobramycin, alone and in combination, in healthy volunteers. No significant alteration in pharmacokinetic behavior was noted for cefoperazone or tobramycin alone or in combination.