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2009•Protein and Peptide LettersRequires access

The Small GTPase Activity of the ROC Domain from LRRK2, a Parkinsons Disease Related Protein

Qingshan Fu, Ai‐Xin Song, Su‐Xia Li, Hong‐Yu Hu

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Abstract

Mutations in the LRRK2 gene have been implicated in the pathogenesis of Parkinsons disease. This work provides biochemical evidence that the ROC domain of LRRK2 functions as a small GTPase, and the Parkinsons disease-associated mutants do not appear to have reduced GTP hydrolysis activities. Keywords: LRRK2, ROC domain, small GTPase, GTP binding, Parkinson's disease

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What this paper is about

Mutations in the LRRK2 gene have been implicated in the pathogenesis of Parkinsons disease. This work provides biochemical evidence that the ROC domain of LRRK2 functions as a small GTPase, and the Parkinsons disease-associated mutants do not appear to have reduced GTP hydrolysis activities. Keywords: LRRK2, ROC domain, small GTPase, GTP binding, Parkinson's disease

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Available abstract

Mutations in the LRRK2 gene have been implicated in the pathogenesis of Parkinsons disease. This work provides biochemical evidence that the ROC domain of LRRK2 functions as a small GTPase, and the Parkinsons disease-associated mutants do not appear to have reduced GTP hydrolysis activities. Keywords: LRRK2, ROC domain, small GTPase, GTP binding, Parkinson's disease

Key concepts: LRRK2, GTPase, GTP', Disease, Pathogenesis, Mutant, Small GTPase, Domain (mathematical analysis)

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