Is Homeostatic Sleep Regulation Under Low Sleep Pressure Modified by Age?

STUDY OBJECTIVES: We have previously shown that healthy older volunteers react with an attenuated frontal predominance of sleep electroen-cephalogram (EEG) delta activity in response to high sleep pressure. Here, we investigated age-related changes in homeostatic sleep regulation under low sleep pressure conditions, with respect to regional EEG differences and their dynamics. DESIGN: Analysis of the sleep EEG during an 8-hour baseline night, during a 40-hour multiple nap protocol (150 minutes of wakefulness and 75 minutes of sleep) and during the following 8-hour recovery night under constant posture conditions. SETTING: Centre for Chronobiology, Psychiatric University Clinics, Basel, Switzerland PARTICIPANTS: Sixteen young (20-31 years) and 15 older (57-74 years) healthy volunteers INTERVENTIONS: N/A. MEASUREMENTS AND RESULTS: All-night EEG spectra revealed an increase in spindle activity (13-15.25 Hz) for both age groups, but only in the young did we find a significant decrease of delta activity (0.5-1.25 Hz) in response to low sleep pressure conditions, predominantly in occipital brain regions. However, delta activity during the first non-rapid eye movement (NREM) sleep episode was equally reduced in both age groups. This response lasted significantly longer in the young (across the first 2 NREM sleep episodes) than in the older participants (only the first NREM sleep episode). CONCLUSION: The initial EEG delta response to low sleep pressure was similar in healthy older and young participants. Therefore, age-related sleep deteriorations cannot solely be attributed to alterations in the homeostatic sleep-regulatory system. It is, rather, the interplay of circadian and homeostatic factors of sleep regulation, which is changed with aging.