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FAILURE OF ADRENERGIC α AND β RECEPTOR BLOCKADE TO ELEVATE THE TSH AND PROLACTIN RESPONSE TO TRH IN HYPERTHYROIDISM

Sol Epstein, B. L. Pimstone, Aaron I. Vinik, Hugh C. McLaren

Open publisher page 6 citations

Abstract

The effects of adrenergic alpha and beta receptor blockade on the thyrotrophin and prolactin responses to TRH were studied in groups of hyperthyroid patients who received either oral propranolol and phenoxybenzamine or intravenous propranolol and rogitine. The flat TSH and prolactin responses to TRH in the untreated hyperthyroid patients were not altered by oral or intravenous adrenergic alpha and beta receptor blockade suggesting that catecholamines do not play a major role in the feedback suppression of TSH and prolactin in hyperthyroidism.

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What this paper is about

The effects of adrenergic alpha and beta receptor blockade on the thyrotrophin and prolactin responses to TRH were studied in groups of hyperthyroid patients who received either oral propranolol and phenoxybenzamine or intravenous propranolol and rogitine. The flat TSH and prolactin responses to TRH in the untreated hyperthyroid patients were not altered by oral or intravenous adrenergic alpha and beta receptor blockade suggesting that catecholamines do not play a major role in the feedback suppression of TSH and prolactin in hyperthyroidism.

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OpenAlex reports 6 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

The effects of adrenergic alpha and beta receptor blockade on the thyrotrophin and prolactin responses to TRH were studied in groups of hyperthyroid patients who received either oral propranolol and phenoxybenzamine or intravenous propranolol and rogitine. The flat TSH and prolactin responses to TRH in the untreated hyperthyroid patients were not altered by oral or intravenous adrenergic alpha and beta receptor blockade suggesting that catecholamines do not play a major role in the feedback suppression of TSH and prolactin in hyperthyroidism.

Key concepts: Endocrinology, Internal medicine, Prolactin, Blockade, Medicine, Receptor, Adrenergic receptor, Hormone

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FAILURE OF ADRENERGIC α AND β RECEPTOR BLOCKADE TO ELEVATE THE TSH AND PROLACTIN RESPONSE TO TRH IN HYPERTHYROIDISM — Research Paper | ScholarLens