1985•Philosophical transactions of the Royal Society of London. Series B, Biological sciencesRequires access

3. Effects of capsaicin on nociceptive afferents from the skin

B. Lynn, Adrian Pini

Abstract

Abstract Capsaicin is a well-known excitant of cutaneous C-fibre nociceptors. In addition it has long-lasting effects on the functions of C-afferents in the rodent. Administration of capsaicin to neonatal rats causes a large reduction in the number of all functional classes of afferent C-fibre (Carpenter & Lynn 1983; Lynn 1984). We have now examined the effects of direct application to cutaneous nerves in adult animals and have found dramatic and selective effects on axonal conduction and nociceptor function.

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Key concepts: Capsaicin, Nociceptor, Nociception, Afferent, Medicine, Neuroscience, Anesthesia, Pharmacology