Structural Modifications to DNA-Binding Polyamides for Improved Biological Activity in Cell Culture

iii Acknowledgements iv I would like to thank my advisor, Professor Peter Dervan, and my fellow Dervanites for creating such a diverse and stimulating place to work. I count myself lucky to have shared a lab with Justin, Ryan, Jim, Christian, and Dave C., both for their scientific prowess and companionship, which made the late nights in lab a lot more fun and a little less frustrating. Katy graciously provided tireless proofreading services, helpful suggestions, and vital material support in the form of baked goods. Puckett knows a lot about almost everything, and I will miss dissecting current events with him. Dan provided invaluable suggestions on a manuscript and a cool head in Dervana. Anne’s sage advice during daily coffee runs is gratefully acknowledged. I would also like to thank Mareike, Nick, Fei, Sherry, Julie, Carey,