The carcinogenic activities in mice of compounds related to 3‐methylcholanthrene

Abstract A number of derivatives of 3‐methylcholanthrene have been tested for carcinogenic action by injection into C57 black mice. 1‐ and 2‐Hydroxy‐3‐methylcholanthrene and 3‐methylcholanthrene‐1‐ and 2‐one were active carcinogens, but cis‐1,2‐dihydroxy‐3‐methylcholanthrene showed only weak activity. The hydrocarbon, 3‐methylcholanthrylene (1,2‐dehydro‐3‐methylcholanthrene). was an active carcinogen. 11,12‐Epoxy‐11,12‐dihydro‐3‐methylcholanthrene showed weak carcinogenic activity whereas cis‐11,12‐dihydro‐11,12‐dihydroxy‐3‐methylcholanthrene was inactive.