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2005•Applied and Environmental MicrobiologyOpen access

Genome-Wide Transcriptional Variation within and between Steady States for Continuous Growth of the HyperthermophileThermotoga Maritima

Keith R. Shockley, Kevin L. Scott, Marybeth A. Pysz, Shannon B. Conners, Matthew R. Johnson, Clemente I. Montero, Russell D. Wolfinger, Robert M. Kelly

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Abstract

Maltose-limited, continuous growth of the hyperthermophile Thermotoga maritima at different temperatures and dilution rates (80 degrees C/0.25 h(-1), 80 degrees C/0.17 h(-1), and 85 degrees C/0.25 h(-1)) showed that transcriptome-wide variation in gene expression within mechanical steady states was minimal compared to that between steady states, supporting the efficacy of chemostat-based approaches for functional genomics studies.

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What this paper is about

Maltose-limited, continuous growth of the hyperthermophile Thermotoga maritima at different temperatures and dilution rates (80 degrees C/0.25 h(-1), 80 degrees C/0.17 h(-1), and 85 degrees C/0.25 h(-1)) showed that transcriptome-wide variation in gene expression within mechanical steady states was minimal compared to that between steady states, supporting the efficacy of chemostat-based approaches for functional genomics studies.

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Available abstract

Maltose-limited, continuous growth of the hyperthermophile Thermotoga maritima at different temperatures and dilution rates (80 degrees C/0.25 h(-1), 80 degrees C/0.17 h(-1), and 85 degrees C/0.25 h(-1)) showed that transcriptome-wide variation in gene expression within mechanical steady states was minimal compared to that between steady states, supporting the efficacy of chemostat-based approaches for functional genomics studies.

Key concepts: Hyperthermophile, Thermotoga maritima, Biology, Genome, Evolutionary biology, Genetics, Computational biology, Bacteria

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