LEUKOCYTOSIS AND NEUTROPHILIA AS PREDICTIVE FACTORS OF ACUTE ON CHRONIC CHOLECYSTITISA Graduating Paper

Background: Acute cholecystitis could progress into chronic cholecystitis, and acute exacerbations of chronic cholecystitis could occur (acute on chronic cholecystitis). Neutrophilia is one of the systemic features of acute inflammation. Typically, leukocytosis in the range of 10,000-15,000 cells per microliter with a left shift on differential count is found. Leukocytosis and neutrophilia were chosen to be studied if they can be predictive factors of acute on chronic cholecystitis. Objectives: The objective of this research is to search whether leukocytosis or neutrophilia can become the predictive factors of acute on chronic cholecystitis. Method: The study design of this research is a retrospective cross-sectional study. The study was conducted among acute cholecystitis and acute on chronic cholecystitis patients with cholelithiasis from year 2010-2013. It was conducted using medical records and laboratory reports of the patients in Sardjito Hospital, Yogyakarta. The data was analysed using computerized analysis. Results: Leukocytosis is a predictive factor of acute on chronic cholecystitis, however, it is not statistically significant (PR=2.364, p=0.129). Neutrophilia is a predictive factor of acute on chronic cholecystitis but is not statistically significant (PR=2.250, p=0.174). Conclusion: Leukocytosis and neutrophilia are not the predictive factors of acute on chronic cholecystitis.