1975•The Tohoku Journal of Experimental MedicineOpen access

Histologic Host Response to Primary Methylcholanthrene-induced sarcomas in Rats Immunized with Allogeneic Tumors

Hajime Kudo, Tatsusuke Sato, YOSHIHIKO KAKISAKA, Shigeki Nishimura, Masafumi Kano, Isamu Usubuchi

Abstract

Lymphocytic infiltration was observed in 44 of 51 (86%) 3-methylcholanthrene (MCA)-induced sarcomas in rats which had been intensively immunized with allogeneic tumors. Eleven of 29 (38%) tumors with intense lymphocytic infiltration and 5 of 15 (33%) tumors with moderate lymphocytic infiltration were "negative" in autologous transplantation. On the other hand, all of 7 tumors accompanied with slight or no lymphocytic infiltration were "positive".

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Key concepts: Lymphocytic infiltration, Infiltration (HVAC), Pathology, Methylcholanthrene, Cellular infiltration, Transplantation, Sarcoma, Medicine