ScholarLens Back to search
1981•Japanese Journal of MedicineOpen access

Two cases of Acute Myelogenous Leukemia with High Terminal Deoxynucleotidyl Transferase Activity responding to Vincristine-Prednisolone treatment with Complete Remission.

Fumimaro Takaku, Keita Hida, Shinobu Sakamoto, Yasuhiko Kano, Masaji Maezawa, Yasusada Miura, Mitsuo Oshimura

Open full text 0 citations

Abstract

Increased TdT activity was demonstrated in 2 cases of AML. One of them had Ph1 positive chromosome due to a standard translocation of t(9:22). Treatment with cytosine arabinoside, daunorubicin, 6-mercaptopurine and prednisolone was ineffective or only partially effective. Switching to the vincristine and prednisolone therapy resulted in a complete remission in both cases.

Open-access reader

About this research paper

What this paper is about

Increased TdT activity was demonstrated in 2 cases of AML. One of them had Ph1 positive chromosome due to a standard translocation of t(9:22). Treatment with cytosine arabinoside, daunorubicin, 6-mercaptopurine and prednisolone was ineffective or only partially effective. Switching to the vincristine and prednisolone therapy resulted in a complete remission in both cases.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Increased TdT activity was demonstrated in 2 cases of AML. One of them had Ph1 positive chromosome due to a standard translocation of t(9:22). Treatment with cytosine arabinoside, daunorubicin, 6-mercaptopurine and prednisolone was ineffective or only partially effective. Switching to the vincristine and prednisolone therapy resulted in a complete remission in both cases.

Key concepts: Terminal deoxynucleotidyl transferase, Prednisolone, Vincristine, Medicine, Leukemia, Complete remission, Internal medicine, TUNEL assay

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Two cases of Acute Myelogenous Leukemia with High Terminal Deoxynucleotidyl Transferase Activity responding to Vincristine-Prednisolone treatment with Complete Remission. — Research Paper | ScholarLens