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2011•Angewandte Chemie International EditionRequires access

Glycan Structure of a High‐Mannose Glycoprotein from Raman Optical Activity

Christian Johannessen, Robert Pendrill, Göran Widmalm, Lutz Hecht, Laurence D. Barron

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Abstract

A revealing signature: The glycan structure of intact yeast external invertase, a high-mannose glycoprotein used as biocatalyst, was investigated by using Raman optical activity (ROA) spectroscopy. The conformational preferences present in mannose-containing di- and trisaccharides were found to be preserved in the glycan chains, with secondary polpeptide backbone structure suppressed.

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A revealing signature: The glycan structure of intact yeast external invertase, a high-mannose glycoprotein used as biocatalyst, was investigated by using Raman optical activity (ROA) spectroscopy. The conformational preferences present in mannose-containing di- and trisaccharides were found to be preserved in the glycan chains, with secondary polpeptide backbone structure suppressed.

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Available abstract

A revealing signature: The glycan structure of intact yeast external invertase, a high-mannose glycoprotein used as biocatalyst, was investigated by using Raman optical activity (ROA) spectroscopy. The conformational preferences present in mannose-containing di- and trisaccharides were found to be preserved in the glycan chains, with secondary polpeptide backbone structure suppressed.

Key concepts: Mannose, Glycan, Glycoprotein, Chemistry, Raman spectroscopy, Biochemistry, Invertase, Enzyme

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